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KMID : 0191120180330370231
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Journal of Korean Medical Science
2018 Volume.33 No. 37 p.231 ~ p.231
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Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia
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Choi Jong-Hyuk
Lee Jae-Woo
Lee Jang-Kyu
Jang So-Yeong
Yoo Mi
Lee Dae-Bo
Hong Jeong-Won
Noh Il-Suk
Lim Myung-Ho
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Abstract
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Background: This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment.
Methods: The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016.
Results: After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported.
Conclusion: These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.
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KEYWORD
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Leuprorelin, Leuprolide Acetate, Sexual Offenders, Paraphilia
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